Do not self-prescribe high-dose B12 based on non-specific symptoms like fatigue without medical assessment
B12 also plays a role in reducing the risk of osteoporosis, improving brain health, and lowering the risk of heart disease
Predrag Sikirics group (School of Medicine, University of Zagreb, 1991 ) Most common experimental dose in animal studies: 10 g/kg intraperitoneally or per os, daily Standard targeted pathways: VEGFR2 angiogenesis, NO synthase , 5-HT2A serotonin receptor, dopamine D2 receptor Clinical program in Croatia halted at Phase 2 (Crohns disease) WADA Prohibited List: added in 2022 to category S0 (Non-Approved Substances) Reference sources (PubMed) Sikiric P
While we always personalize treatment, heres a general starting point we use when creating a plan: Dosage: 250 to 500 mcg per day Method: Subcutaneous injection near the affected joint Cycle: 4 weeks on, followed by 2 to 4 weeks off Duration: Usually 1 to 3 cycles, depending on severity Injectable BPC-157 is preferred for arthritis
High doses of B12 may cause: What to Expect After Treatment If you have anemia, itll likely get better in 6-8 weeks