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DNA Synthesis: B12 is involved in the production of DNA, making it a crucial nutrient for cell division and growth

Combining it with another GLP-1 or GIP agonist (semaglutide, tirzepatide) would compound the same receptor load and the same GI and hypoglycemia risks with no efficacy evidence to support it

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In a large network meta-analysis of data from 102,257 participants, pooled results suggested a neutral relationship between GLP-1 receptor agonists and acute pancreatitis (relative ratio 0.96, 95% confidence interval 0.313.00)