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Cell 110 , 673687 (2002)

It is contraindicated in patients with a personal or family history of medullary thyroid cancers (MTC) or patients with multiple endocrine neoplasia syndrome type 2 (MEN2).[] FUTURE INDICATIONS AND TRIALS Oral semaglutide has been explored with higher doses of 25 and 50 mg in ongoing PIONEER plus trials.[] Another trial under the name PIONEER TEEN is ongoing to see the efficacy and safety of semaglutide in children and teenagers with age 10 years to 17 years.[] PIONEER REAL is a global prospective, non-interventional single-arm real-world study with oral semaglutide.[] EVOKE and EVOKE plus are ongoing trials to see the effect of oral semaglutide in Alzheimers disease.[] SOUL is an ongoing CV superiority trial with an objective to prove CV benefits with this molecule