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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

The lactylation labeling is recognized by specific reader proteins, which play a critical role in gene expression regulation during macrophage polarization, neuronal synaptic plasticity, and stress responses by altering chromatin accessibility or recruiting transcription factors (Hagihara et al., 2021)

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This is particularly relevant in contexts like NSAID-induced gastric ulcers, where the problem isn't just lack of healing but active ongoing damage