glp-1/gcgr dual agonist Evaluation of biased agonism mediated by agonists of the GLP-1 and glucagon receptors Effects, working principles and target

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Mechanistic studies have attributed these effects to the inhibition of nuclear factor-kappa B (NF-B) phosphorylation, a critical upstream regulator of inflammasome priming (Sui et al., 2016)

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