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found that base modification could considerably reduce the hepatotoxicity of gapmer ASO, 245 providing insights for developing new gapmer ASOs

The patent gives exceedingly little information about the isolation process, stating only that a variety of relatively crude chromatographic approaches were utilized (i.e., ion-exchange and gel) followed by dialysis (i.e

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Significant fat loss and muscle gains are typically most prominent at the 3 to 6 month mark