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A previous report showed that activated glial cells can participate in the death of dopaminergic neurons, probably by the activation of apoptosis by cytokines like TNF-, IL-1B, IL-6 and interferon- and the subsequent production of nitric oxide (NO) by the iNOS that may diffuse toward the neurons and induce lipid peroxidation, DNA strands breaks and inhibition of mitochondrial metabolism [6,10]

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Notably, weight reduction had not plateaued by 52 weeks, indicating potential for further loss with longer use