For example, in our evaluation of postmortem human brain tissue from individuals with various levels of AD neuropathology, we observed a wide range (0-15%) of senescent cell burden (39)
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Alternatively, and preferably for ultimate manufacturing, a concentrated ethanolic niclosamide can be mixed by solvent exchange into pH buffers to make the solutions in literally 1-2 seconds, as demonstrated in the rapid injection technique in Figure 1
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In clinical practice, most reactions are related to technique, tissue sensitivity, or formulation not the peptide itself