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Another study in 2013 indicated that oral administration of the total flavonoids (TFs) from Rosa laevigata Michx fruit decreased blood lipid and glucose levels and ameliorated hepatic fat accumulation through suppressing fatty acid synthesis, promoting fatty acid b-oxidation together with resisting oxidant stress and protecting mitochondria, indicating that TFs provides novel therapeutic potential against HFD-induced NAFLD (Zhang et al., 2013)

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