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The most common reason cause of the Jarisch-Herxheimer Reaction are taking high doses of antifungals or antibiotics, but the condition can also occur when rapid changes of diet cause large-scale die-off of gut microflora overgrowth (also see: SIBO Diet)

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However, the source paper contains inconsistent descriptions of the SPR concentration rangethe figure legend specifies 23.4496,000 nM, whereas the methods section lists 1.8931.25 nM, a discrepancy of several thousand-fold

These tumors are characterized by a propensity for metastasis and frequently diagnosed at advanced stages, contributing to elevated mortality rates