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In three-dimensional space, V730 is located near the coactivator binding site 84 and, along with M734 and I737 in the hydrophobic groove, allows the formation of a smoother and flatter surface that permits greater complementarity to FxxLF compared with the LxxLL motif (Figure 7C)

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Author contributions LC and LL contributed to conception and study design, and took responsibility for the collection, integrity, and accuracy of the data

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Additionally, sleep disorder history and iron deficiency anemia (IDA) were used as covariates