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[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects

Patients taking both medications typically experience more sustained weight loss over 1224 weeks compared to semaglutide monotherapy, particularly when starting metformin at a standard dose of 5001000 mg daily and increasing semaglutide gradually from a low microdose

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