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All current use of retatrutide remains strictly research-use-only.

Animal data Reproduction studies have been performed in rats at 20 mg/kg/day (0.13 times the maximum recommended human daily dose of 1,500 mg/day based on body surface area comparison) rabbits at 20 mg/kg/day (0.26 times the maximum recommended human daily dose, based on body surface area comparison), and mice at 170 mg/kg/day (0.6 times the maximum recommended human daily dose based on body surface area comparison) with no evidence of impaired fertility or harm to the fetus due to the drug

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IGF-1 levels are also highly influenced by nutritional intake, which might hold greater significance from an evolutionary standpoint, as the primary signaling pathways triggered by IGF-1 in metazoans were originally activated by nutrient availability (34)

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