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We show that local Ex4 injection leads to increased neuronal activation of MCs in the OB

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However, prolonged activation of AMPK by AICAR has been reported to trigger beta cell apoptosis 32,33

(3) an alternative condensation of -glutamyl phosphate synthesized by -glutamyl kinase (Pro1 or ProB) with cysteine to form -glutamylcysteine which was further conjugated to glycine by glutathione synthetase