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Some evidence suggests that periodic breaks, 1 to 2 weeks off every 8 to 12 weeks, can reset receptor sensitivity

10 After attainment of steady state following 4 days of oral administration of CARNITOR Tablets (1980 mg q12h) or Oral Solution (2000 mg q12h) to 15 healthy male volunteers, the mean urinary excretion of levocarnitine during a single dosing interval (12h) was about 9% of the orally administered dose (uncorrected for endogenous urinary excretion)

Appetite Dysregulation Hypothyroidism affects leptin and ghrelin (hunger hormones)