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The researchers found that randomization to GLP-1 RA treatment among all included trials was associated with increased risks for gallbladder or biliary diseases (pooled relative risk [RR], 1.37), specifically cholelithiasis, cholecystitis, and biliary disease (RRs, 1.27, 1.36, and 1.55, respectively)
One additional Phase III trial is assessing whether Survodutide can help overweight or obese individuals, as well as diagnosed or suspected MASH patients, reduce liver fat and lose weight
Subsequent drugs like liraglutide and semaglutide are engineered modifications of the human GLP-1 sequence, not lizard-derived
An average person starting GLP-1 medications for weight loss have been cited as averaging approximately 2.3% of their body weight in this same period
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