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The central nervous system theory focuses on brain effects

In addition to lowering blood glucose, reducing food intake, and delaying gastric emptying ( GLP-1RA has a wide range of pharmacological effects

First cardiovascular safety trial of a DPP-4 inhibitor in patients with T2DM and high cardiovascular risk, showing that saxagliptin does not augment MACE but increases hospitalization for heart failure

Fiber from intact grains, legumes, fruits, and vegetables slows digestion, feeds beneficial gut bacteria, and triggers GLP-1 release further down the intestinal tract, where most of those hormone-producing cells live