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When GLP-1 RAs were associated with higher risk, the number needed to harm (NNH) was calculated as the reciprocal of the absolute risk increase, representing the number of patients who would need to be treated for one additional event to occur

Most events are reported as mild-to-moderate and tend to diminish over time as the body adapts

This suggests that mitochondrial metabolism not only regulates cellular energy status but also plays a critical role in maintaining genomic stability

Melatonin was most effective in enhancing learning ability in senescence-related and metabolic AD models and in correcting memory deficits in toxin-induced AD models