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Participants were randomly assigned to one of five therapies: exenatide alone, dapagliflozin alone, dual therapy of exenatide and dapagliflozin, combined dapagliflozin and metformin therapy, or the weight-loss medication phentermine/topiramate extended-release

Add resistance training two to three times per week to maintain muscle mass and boost metabolism

For some people, weeks 3 and 4 bring a slight reduction in the appetite-suppressing effect compared to week 1