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It is important to consult with healthcare providers about personal hydration needs in relation to individual health circumstances and medication usage

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Suicidal Thinking and Behavior Counsel patients, their caregivers, and families that AEDs, including valproic acid, may increase the risk of suicidal thoughts and behavior and to be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm

Jumping to high doses too quickly dramatically increases nausea, vomiting, and other GI symptoms without producing faster weight loss

Cell 145 , 341355 (2011)