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Neither step alone produces the best result

Single and dual agonists The fundamental difference between these two molecules is that semaglutide is a GLP-1 agonist, i.e., it has a strong structural similarity (95%) with this hormone and specifically activates its receptor, while tirzepatide is a dual agonist, i.e., it has a hybrid structure that allows it to activate both GLP-1 and GIP receptors (Figure 2)

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At the single neuron level, this translates into waves of post-translational protein modifications and new gene expression that ultimately promote long-term stabilization of changes in synaptic strength (Flavell and Greenberg, 2008)