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However, studies on targeted segments of the population have shown that the upper limit of 15mol/L is far too high in well-nourished populations without obvious vitamin deficiency

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Plasma half-life estimates range from 30-60 minutes based on limited animal and human studies, though systematic pharmacokinetic characterization in humans has not been published

One-carbon metabolism is essential for DNA methylation and synthesis, with methionine serving as the main methyl group donor

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