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Additionally, polyamines maintain redox homeostasis through enhancement in the activation of the antioxidative system, reduction in lipid peroxidation, stabilization of cell membrane, induction of PR-proteins, SAR, HR and interaction with defence-associated hormones [175]

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These measures are summarized here for the busy clinician, as are highly valuable diagnostic modalities that have emerged in the last decade, such as high resolution ultrasound (done in-office in many rheumatology practices) and dual-energy computed tomography (DECT) imaging

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Its thiol (-SH) group is the key functional site responsible for its wide range of biochemical activities

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