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As shown in Table 1 , inhibitors or antagonists of these targets have shown good results in animals, such as CXCR3, CXCR4, CXCL10, CXCL12, and CXCL13, especially the antibody of CXCL10 (MDX-1100) has entered clinical trials (25) ( Figure 2 )

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Check competition and International Federation rules to understand when the in-competition period starts and when your use of tramadol may occur in relation to that time period