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but also potential for increased risk of disordered eating, anxiety, or emotional distress in certain populations

William Yi Months 6 and Beyond Weight loss continues but slows down

There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

Higher doses increase GI side effects (nausea, vomiting, diarrhea) in 2530% of users, particularly during escalation phases

Half-Life and Dosing The CJC-1295 component extends the effective window considerably