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In all the groups, 5 to 14% of participants discontinued any trial because of adverse events (AE)

Discuss with your provider whether dose tapering, timing adjustments, or alternative approaches might smooth your transition and reduce regain risk

The history of promising Phase 2 drugs that didn't pan out in Phase 3, or revealed safety signals only visible in larger populations, is long

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In the United States, FDA approved four-dose Mounjaro and Zepbound KwikPens on January 20, 2026, while single-dose Mounjaro and Zepbound pens and vials also remain in use