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Flavonoids as GLP-1R Agonists Several flavonoids have been shown to enhance GLP-1 secretion in intestinal cell models and tissues, leading to increased plasma GLP-1 concentrations in animal studies

Long-term retention: The accumulation of MNPs in tissues raises concerns about chronic inflammation or interference with normal physiological processes

GLP-1 receptor agonists pass the bloodbrain barrier and directly engage with GLP-1 receptors in essential appetite-regulating sites of the hypothalamus and brainstem (Trapp and Brierley 2022)

Psychopharmacology 237, 35393552

Consequently, the potential interplay between ERS and NAD + levels in the context of fatty liver disease warrants further investigation