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Track specific markers including pain levels (using a consistent 0-10 scale), range of motion, visible swelling, and functional capacity

Nature Communications (2025) 9

Follow-up care also involves monitoring for symptoms related to B12 deficiency, such as fatigue, weakness, and neurological changes, to assess the effectiveness of treatment

Senolytic drugs: from discovery to translation Kirkland JL, Tchkonia T Journal of Internal Medicine (2020) This comprehensive review from the Mayo Clinic's leading senescence researchers places FOXO4-DRI within the broader context of senolytic drug development and clinical translation