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Hence, incretinbased treatments, particularly GLP1 receptor agonists and dual GIP/GLP1 agents, are being considered for their broader metabolic benefits

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Eventually, companies reduced price, and NICE granted full approval in 2023 for pembrolizumab in several indications at negotiated price, while ICER still lists its value-based price about 50% below U.S

Studies in animal models suggested that activating the GLP-1 receptors (GLP-1Rs) in the brain improves neuroinflammation, neurogenesis, and synaptic plasticity