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John Horneff, an associate professor of orthopedic surgery at the University of Pennsylvania and the lead author of the study, said he began looking into the issue after some patients appeared to develop serious tendon tears after relatively minor injuries
Taking a dose at night may support these nocturnal repair processes
49 As a core circadian regulator, melatonin stabilizes clock genes (e.g., CLOCK protein), reduces cortisol-mediated immunosuppression, and coordinates rhythmic immune cell activities (e.g., diurnal fluctuations in macrophage phagocytosis), systemically delaying immunosenescence
