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doi: 10.3389/fimmu.2021.711650 17 LeeLYYIzzardLHurtAC
The UDPglucuronic acid is the most important cosubstrate involved in the conjugation reactions (called glucuronidation) carried out by UGTs
Glutathione helps neutralize these oxidants and protects mitochondria and cell membranes
Enhanced DNA repair capacity explains GHK-Cus ability to restore replicative vitality to irradiated fibroblasts, normalizing growth dynamics to non-irradiated control levels
Further, the increase in mtROS production correlated with a decline in the expression and activity of the mitochondrial antioxidant enzyme Mn +2 superoxide dismutase (MnSOD), and a decline in the cytosolic glutathione peroxidase (GPx) activity and GSH content in the myocardium of chronically infected animals (Wen and Garg, 2004) and in ChD patients (Prez-Fuentes et al., 2003
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