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According to a peer-reviewed clinical review in the National Library of Medicine summarizing GHK-Cus role in tissue remodeling and skin regeneration, the peptide has been documented in clinical research since the early 1970s and remains one of the most validated copper-binding peptides in dermatologic use

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Aggregated -synuclein fibrils, dopamine-derived quinones, and mitochondrial DAMPs, including cardiolipin and mtDNA, are strong inducers of microglial NLRP3 inflammasome activation in PD