In summary, natural products such as oleanolic acid, resveratrol, and curcumin embody the hallmarks of multi-target metabolic regulation by simultaneously regulating glycolysis, mitochondrial function and oxidative stress, lipid metabolism, and amino acid metabolism, highlighting their unique ability to reprogram tumor metabolism and exert comprehensive anticancer effects
For individuals with obesity, type 2 diabetes, or cardiovascular risk factors, the documented benefits of GLP-1 medications on weight, blood sugar, cardiovascular outcomes, and in some cases kidney and liver health are substantial
Complete somatic genomics (DNA, RNA-seq and miRNA-seq) for all participants, with proteomics and PTMs for 162 participants, metabolomics and lipidomics for 97 participants and matched normal DNA for 161 participants were collected (Extended Data Fig
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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Khan H., Singh T.G., Dahiya R.S., Abdel-Daim M.M
