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Cardiovascular outcomes trial SURPASS-CVOT (NCT04255433) is ongoing

Sulfonylureas can cause hemolytic anemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency and therefore should be used with caution in such patients (Package insert)

For now, DHK-Cu remains an intriguing piece of the puzzleone that may yet prove more significant than its current obscurity suggests

Preparative Biochem (1972) 2(4):34754

Standard Titration Schedule The most common titration approach increases doses every 2-4 weeks in 50-100mcg increments until reaching optimal response or maximum tolerated dose