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JACC Heart Fail 3(2):136145

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Escin protects against acetaminophen-induced liver injury in mice via attenuating inflammatory response and inhibiting ERK signaling pathway

Potential benefits include preventing early pregnancy loss and limiting excess GWG in PCOS pregnancies, 22 but there are conflicting reports regarding its efficacy for other outcomes such as GDM, preterm birth, and preeclampsia

The only exception is canagliflozin, which causes delayed ossification of the metatarsal bones that may be attributed to effects on calcium homeostasis observed in earlier studies in healthy human adults (70)