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The science on this is overwhelming

The same systems that antidepressants target

They are particularly valuable for individuals with dietary restrictions or absorption issues who may not receive adequate B-12 from their diet alone

GLP-1-driven weight loss depletes all three simultaneously

Specifically, the efficient execution of fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS)the core metabolic pathways fueling the M2 phenotypeis severely compromised in the diabetic milieu (Purvis et al., 2024