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In conclusion, available preclinical evidence suggests that the neuromodulatory actions of THC are characterized by a dual, largely dose-dependent profile

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it also causes systemic inflammation that breaks down cartilage and bone, leaving people doubting their ability to live their daily lives

256 This dual action is partly mediated by the reduction in IGF-1 and glucose levels, thus shielding normal cells and organs from chemical toxicity

HA and IR can exacerbate endothelial damage and disrupt endothelium-dependent vasodilation mechanisms, leading to vascular smooth muscle hypertrophy and lipid metabolism disorders (Krentowska and Kowalska, 2022