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Although the number of beige adipocytes did not increase, they displayed a more thermogenic phenotype characterized by smaller LDs, elevated expression of uncoupling protein 1 ( UCP1 ) and HSL , and enhanced glucose utilization, all features consistent with increased mitochondrial uncoupling and browning

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Medication data included semaglutide dosing categorized as low dose (0.25 to 1 mg weekly) and high dose (1.7 to 2.4 mg weekly), and dose and type of systemic HRT (transdermal or oral estrogen and progestogen use)

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