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Interestingly, the same results were not observed in healthy age-matched mice, as 6 weeks of progressive ladder-climbing RT (3 climbs, progression from 50% to 100%MCL, 5 times per week) decreased lipid peroxidation in the cerebral cortex but increased lipid peroxidation in the hippocampus (Feter et al., 2019)

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In some embodiments, the otic formulation or composition comprises about 11% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

LKB1 phosphorylates and activates AMP-activated protein kinase (AMPK), which functions as an energetic sensor, regulating glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels [7]

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