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Further, the process of the present invention provides advantages, such as environmental friendliness due to the use of an immobilized enzyme in the preparation of the intermediate, and applicability thereof to industrial-scale production arising from decreased production costs due to the recyclability of the enzyme

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Because the anti-inflammatory mechanism works through normal GLP-1 pathway activation rather than immune suppression, serious infections or immunocompromise are not concerns

We also proposed that if the calculated percentile falls between two observed allowed amounts, the 90th percentile allowed amount is the next highest observed value

One injection per day: once daily, every day, for the full 10 day course