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However, under certain conditions, SIRT1 activation may exacerbate oxidative injury depending on NAD + availability, tissue microenvironment, and timing

In a study utilizing the catalase inhibitor 3-amino-1,2,4-triazole (3-AT), the inhibition of catalase was investigated to ascertain the impact on Brucella abortus intracellular proliferation within RAW 264.7 macrophage cells and an ICR mice model during Brucella infection

Neurobiol Aging 1995;16:1-4

The sulphur atom on cysteine carries a hydrogen, forming the thiol group (-SH) that gives glutathione its working surface

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