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Erythromycin antagonises the deceleration of gastric emptying by glucagon-like peptide 1 (GLP-1) and unmasks its insulinotropic effect in healthy subjects

Nonetheless, the widespread distribution of these receptors raises concerns about potential unintended physiological effects associated with GLP-1RAs

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Thus, GLP-1 analogues, such as exenatide and liraglutide, and the DPP-4 inhibitors which lower glucose levels by GLP-1 mediated effects, appear to have a very low incidence of hypoglycemia in clinical trials (Figure 13.6)