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There are currently an equal number of studies in SGLT2i and dual SGLT2i/SGLT1i therapy reporting both an increased [32,33,34] and decreased risk of DKA at maximal permitted doses [34,35,36] when compared with minimally licensed doses

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As a result, melasma tends to worsen during the sunny, hot summer months when the skin is more exposed to sunlight, which can cause the patches to darken