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Control of glutamine metabolism by hypoxia Hypoxic conditions promote the uptake of glutamine by increasing the levels of glutamine transporters such as SLC1A5, the SLC1A5 variant, and SLC38A2 16,65 and switch the fate of glutamine from the oxidative pathway into the reductive carboxylation pathway 24

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Day 61 or thereafter if : If no additional glycemic control is needed, then maintain the dosage at 4 mg orally once daily

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