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Since the more mildly-affected participants often responded well to cofactor therapy alone, and that the side effects of the cofactors are generally much less than that of the medications [5 and author's experience], a trial of cofactor and dietary therapy alone may be warranted in most CVS patients encountered in clinical practice, with amitripyline or cyproheptidine added in refractory cases

She said: "There are no clinical studies published as scientific articles

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During oxidative phosphorylation, a small fraction of electrons leaks from Complexes I and III of the electron-transport chain, reducing molecular oxygen to superoxide (O)