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Confocal imaging of wildtype vs TMEM55B KO cells stained for endogenous LAMP2 to mark lysosomes, paired with automated image analysis by OrgaMapper 39 revealed the accumulation of lysosomes in the cell periphery in TMEM55B KO cells, in agreement with previous work using siRNA 11,31 (Fig

At 1.7 mg, most people experience strong appetite suppression throughout the entire week between injections, with minimal return of hunger before the next dose