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Furthermore, the number of L cells and postprandial plasma GLP-1 secretion decreases in rats fed an obesogenic high-fat diet (HFD) [30]
The increased cAMP levels in cardiac cells activate exchange protein directly activated by cAMP (EPAC) and protein kinase A (PKA), which regulate a multitude of downstream effectors involved in cardiac contractility, relaxation, and hypertrophy [14]
Injection site reactions are a common side effect of GLP-1s like semaglutide or tirzepatide, affecting around 1% to 8% of people taking the medications
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Improvements were also noted in waist size, lipid levels, and blood pressure
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