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Insulins builtin preservatives inhibit bacterial growth Commercial insulin formulations contain bacteriostatic agents (phenol, metacresol) that effectively prevent microbial proliferation inside the cartridge even if a small number of skin bacteria are carried in during injection (PubMed, PubMed)

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If you have a mental health condition, such as depression, you may have an increased risk of this side effect

[5] Whilst headaches are reported, they remain less common than gastrointestinal adverse effects such as nausea, vomiting, and diarrhoea, which the SmPC lists as 'very common' (affecting more than 1 in 10 patients)