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Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH

Using a socio-technical lens (Geels, 2005), we analyze three medium-sized municipalities in a peripheral European region undergoing service transformation

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