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Some older studies examined combinations of weaker GLP-1 drugs with DPP-4 inhibitors, showing modest additional glucose lowering compared to either drug alone, but the incremental benefit did not justify the added complexity and cost for most patients

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Les essais cliniques montrent un signal : la supplmentation orale 250-500 mg/jour pendant 4 12 semaines rduit modestement l'indice de mlanine, principalement dans les zones cutanes exposes au soleil